hnRNP E1/PCBP1 Rabbit Monoclonal Antibody (CAB19276)
- SKU:
- CAB19276
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- PCBP1
- HEL-S-85
- HNRPE1
- HNRPX
- hnRNP-E1
- hnRNP-X
- poly(rC)-binding protein 1
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | hnRNP E1/PCBP1 Rabbit Monoclonal Antibody |
SKU: | CAB19276 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PCBP1 (Q15365). |
Sequence: | MDAG VTES GLNV TLTI RLLM HGKE VGSI IGKK GESV KRIR EESG ARIN ISEG NCPE RIIT LTGP TNAI FKAF AMII DKLE EDIN SSMT NSTA ASRP PVTL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | HNRPX; HNRPE1; hnRNP-X; HEL-S-85; hnRNP-E1; hnRNP E1/PCBP1 |
Positive Sample: | HeLa,HepG2,A-431,K-562,Mouse lung,Mouse brain,Rat pancreas |
Conjugate: | Unmodified |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 37kDa |
Observed MW: | 40kDa |
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.
Purification Method: | Affinity purification |
Gene ID: | 5093 |
Clone Number: | ARC2456 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |