The Anti-GSDMD Antibody (CAB20728) is a valuable tool for researchers studying Gasdermin D (GSDMD), a key protein involved in pyroptosis, a form of programmed cell death. This antibody, produced in rabbits, is specifically designed for use in detecting GSDMD in human samples and is validated for use in Western blot applications. By binding to GSDMD, this antibody allows for the detection and analysis of GSDMD levels in various cell types, making it essential for studies in immunology and oncology research.GSDMD is a crucial player in the innate immune response, mediating the release of pro-inflammatory cytokines and inducing cell death in response to infection or cellular stress.
Dysregulation of GSDMD has been implicated in various inflammatory diseases, making it a promising target for therapeutic interventions. Research on GSDMD is vital for understanding the mechanisms underlying inflammation and cell death, with implications for the development of novel treatments for inflammatory and infectious diseases.
Product Name:
GSDMD Monoclonal Antibody
SKU:
CAB20728
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 346-484 of human GSDMD (NP_079012.3).
Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described.
Purification Method:
Affinity purification
Gene ID:
79792
Clone Number:
ARC50993
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from A-431 cells, using GSDMD Rabbit mAb (CAB20728) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
