The Exoc3 Polyclonal Antibody (CAB20925) is an essential tool for researchers investigating the Exoc3 protein, a key player in the process of membrane trafficking and exocytosis. This antibody, produced in rabbits, exhibits high specificity for human samples and is suitable for use in Western blotting applications. By binding to the Exoc3 protein, this antibody enables precise detection and analysis of this important molecule in a variety of cell types, making it an invaluable asset for studies in cell biology and neuroscience.Exoc3 is a crucial component of the exocyst complex, which coordinates the delivery of vesicles to the plasma membrane during various cellular processes, including neurotransmitter release and cell migration.
Understanding the function and regulation of Exoc3 is essential for unraveling the mechanisms underlying these fundamental cellular functions. By targeting Exoc3, researchers can gain insights into diseases involving dysregulated exocytosis, such as neurodegenerative disorders and cancer, paving the way for the development of novel therapeutic strategies.
Product Name:
EXOC3 Monoclonal Antibody
SKU:
CAB20925
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 650-745 of human EXOC3 (O60645).
cytosol, exocyst, Golgi apparatus, growth cone, perinuclear region of cytoplasm, presynaptic membrane
Calculated MW:
86kDa
Observed MW:
85kDa
The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.
Purification Method:
Affinity purification
Gene ID:
11336
Clone Number:
ARC2900
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using EXOC3 antibody (CAB20925) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
