The Ceruloplasmin Polyclonal Antibody (CAB20229) is a specialized research tool targeting ceruloplasmin, a key protein involved in copper transport and iron metabolism. This antibody, generated in rabbits, exhibits high affinity and specificity for ceruloplasmin in human samples, enabling precise detection and analysis in various experimental settings.Ceruloplasmin, a multi-functional protein primarily produced in the liver, plays a crucial role in maintaining copper homeostasis and facilitating iron oxidation. Dysregulation of ceruloplasmin is implicated in various diseases, including Wilson's disease and Alzheimer's disease, highlighting its significance in physiological processes and pathogenesis.
By utilizing the Ceruloplasmin Polyclonal Antibody, researchers can delve into the intricate functions of ceruloplasmin in health and disease. This antibody is validated for applications such as Western blotting, immunohistochemistry, and immunofluorescence, making it a versatile tool for studies in fields such as biochemistry, neuroscience, and metabolism. Gain valuable insights into the molecular mechanisms underlying ceruloplasmin biology and its potential as a therapeutic target with this advanced research reagent.
Product Name:
Ceruloplasmin Rabbit Monoclonal Antibody
SKU:
CAB20229
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 366-572 of human Ceruloplasmin (NP_000087.1).
The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1356
Clone Number:
ARC5018-06
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Ceruloplasmin Rabbit mAb (CAB20229) at 1:5000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
