The ALOX15B Polyclonal Antibody (CAB6865) is a valuable tool for researchers studying ALOX15B, an enzyme involved in the metabolism of lipid mediators and regulation of inflammation. This antibody, generated in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the ALOX15B protein, this antibody allows for accurate detection and analysis in various cell types, making it well-suited for studies in the fields of immunology and inflammation research.
ALOX15B, also known as arachidonate 15-lipoxygenase type B, plays a crucial role in the biosynthesis of lipid mediators involved in inflammatory processes. Its dysregulation has been implicated in various inflammatory diseases, making it a promising target for therapeutic interventions. Research into the function of ALOX15B could provide valuable insights into the pathogenesis of inflammatory conditions such as asthma, atherosclerosis, and cancer, potentially leading to the development of novel treatment strategies.
Product Name:
ALOX15B Rabbit Polyclonal Antibody
SKU:
CAB6865
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human ALOX15B (NP_001132.2).
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
247
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using ALOX15B Rabbit pAb (CAB6865) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
