The ALG2 Polyclonal Antibody (CAB7843) is a valuable tool for researchers studying ALG2, a protein involved in various cellular processes such as apoptosis and calcium homeostasis. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the ALG2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component for research in cell biology and molecular biology.
ALG2 is known for its role in apoptosis regulation and calcium signaling, making it a key player in cellular survival mechanisms. Research into ALG2 has implications for understanding diseases such as neurodegeneration, cancer, and metabolic disorders, where dysregulation of apoptosis and calcium signaling are common features. By targeting ALG2, researchers can uncover new insights into the molecular mechanisms underlying these diseases and potentially identify novel therapeutic targets for intervention.
Product Name:
ALG2 Rabbit Polyclonal Antibody
SKU:
CAB7843
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 197-416 of human ALG2 (NP_149078.1).
This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii). Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
85365
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ALG2 antibody (CAB7843) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Basic Kit (AbGn00020)._Exposure time: 90s.
