The ALDH7A1 Polyclonal Antibody (CAB8629) is a valuable tool for researchers studying ALDH7A1, an enzyme involved in the metabolism of aldehydes and amino acids. This antibody, produced in rabbits, is highly specific for human samples and is validated for use in Western blot applications. By targeting the ALDH7A1 protein, this antibody allows for the detection and analysis of ALDH7A1 expression in a variety of cell types, making it suitable for studies in metabolism, neurology, and genetic disorders.ALDH7A1, also known as antiquitin, plays a crucial role in the detoxification of harmful aldehydes and the biosynthesis of amino acids such as lysine and tryptophan.
Mutations in the ALDH7A1 gene have been linked to pyridoxine-dependent epilepsy, a rare metabolic disorder affecting the central nervous system. By understanding the functions and regulation of ALDH7A1, researchers can gain insights into the pathogenesis of metabolic diseases and potentially uncover new therapeutic targets for these conditions.
Product Name:
ALDH7A1 Rabbit Polyclonal Antibody
SKU:
CAB8629
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 430-539 of human ALDH7A1 (NP_001173.2).
The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein. It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix. Recent reports show that this protein is found both in the cytosol and the mitochondria, and the two forms likely arise from the use of alternative translation initiation sites. An additional variant encoding a different isoform has also been found for this gene. Mutations in this gene are associated with pyridoxine-dependent epilepsy. Several related pseudogenes have also been identified.
Purification Method:
Affinity purification
Gene ID:
501
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using ALDH7A1 Rabbit pAb (CAB8629) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Negative control (NC): K-562.Exposure time: 75s.
