ALAD Rabbit Polyclonal Antibody (CAB8398)
- SKU:
- CAB8398
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- IF
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | ALAD Rabbit Polyclonal Antibody |
SKU: | CAB8398 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-330 of human ALAD (NP_000022.3). |
Sequence: | MQPQ SVLH SGYF HPLL RAWQ TATT TLNA SNLI YPIF VTDV PDDI QPIT SLPG VARY GVKR LEEM LRPL VEEG LRCV LIFG VPSR VPKD ERGS AADS EESP AIEA IHLL RKTF PNLL VACD VCLC PYTS HGHC GLLS ENGA FRAE ESRQ RLAE VALA YAKA GCQV VAPS DMMD GRVE AIKE ALMA HGLG NRVS VMSY SAKF ASCF YGPF RDAA KSSP AFGD RRCY QLPP GARG LALR AVDR DVRE GADM LMVK PGMP YLDI VREV KDKH PDLP LAVY HVSG EFAM LWHG AQAG AFDL KAAV LEAM TAFR RAGA DIII TYYT PQLL QWLK EE |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | PBGS; ALADH; ALAD |
Positive Sample: | U-251MG,MCF7,22Rv1,HL-60 |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol, extracellular exosome, extracellular region, nucleus |
Calculated MW: | 36kDa |
Observed MW: | 35kDa |
The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 210 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |