AIPL1 Rabbit Polyclonal Antibody (CAB6458)
- SKU:
- CAB6458
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
Product Name: | AIPL1 Rabbit Polyclonal Antibody |
SKU: | CAB6458 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-384 of human AIPL1 (NP_055151.3). |
Sequence: | MDAA LLLN VEGV KKTI LHGG TGEL PNFI TGSR VIFH FRTM KCDE ERTV IDDS RQVG QPMH IIIG NMFK LEVW EILL TSMR VHEV AEFW CDTI HTGV YPIL SRSL RQMA QGKD PTEW HVHT CGLA NMFA YHTL GYED LDEL QKEP QPLV FVIE LLQV DAPS DYQR ETWN LSNH EKMK AVPV LHGE GNRL FKLG RYEE ASSK YQEA IICL RNLQ TKEK PWEV QWLK LEKM INTL ILNY CQCL LKKE EYYE VLEH TSDI LRHH PGIV KAYY VRAR AHAE VWNE AEAK ADLQ KVLE LEPS MQKA VRRE LRLL ENRM AEKQ EEER LRCR NMLS QGAT QPPA EPPT EPPA QSST EPPA EPPT APSA ELSA GPPA EPAT EPPP SPGH SLQH |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:100 |
Synonyms: | LCA4; AIPL2; AIPL1 |
Positive Sample: | Mouse liver,Mouse heart |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 44kDa |
Observed MW: | 40-45kDa |
Leber congenital amaurosis (LCA) is the most severe inherited retinopathy with the earliest age of onset and accounts for at least 5% of all inherited retinal diseases. Affected individuals are diagnosed at birth or in the first few months of life with nystagmus, severely impaired vision or blindness and an abnormal or flat electroretinogram. The photoreceptor/pineal-expressed gene, AIPL1, encoding aryl-hydrocarbon interacting protein-like 1, is located within the LCA4 candidate region. The encoded protein contains three tetratricopeptide motifs, consistent with chaperone or nuclear transport activity. Mutations in this gene may cause approximately 20% of recessive LCA. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 23746 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |