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Low Endotoxin Purified Anti-Mouse CD161/NK1.1 Antibody [PK136] (AGEL0479)

SKU:
AGEL0479
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
€229 - €1,219
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Description

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Low Endotoxin Purified Anti-Mouse CD161/NK1.1 Antibody [PK136]

The Mouse CD161/NK1.1 Monoclonal Antibody (PK136) is a specialized research tool designed for the detection and analysis of CD161/NK1.1, a cell surface marker associated with natural killer cells and other immune cell subpopulations. This antibody, produced through purification processes, exhibits high specificity and sensitivity for mouse samples, making it an invaluable tool for immunology research.CD161/NK1.1, also known as NKR-P1C, is a marker that helps identify and study specific subsets of immune cells, particularly natural killer cells, NKT cells, and subsets of T cells. Understanding the expression and function of CD161/NK1.

1 is essential for unraveling the intricacies of immune responses and exploring potential therapeutic targets for various immune-related disorders.With its ability to selectively bind to CD161/NK1.1 antigens, the PK136 monoclonal antibody enables researchers to pinpoint and characterize these specialized immune cell populations in diverse experimental settings. Whether investigating immune cell dynamics, studying immune system interactions, or developing novel immunotherapies, this antibody offers a precise and reliable tool for advancing immunological studies.

Product Title:Low Endotoxin Purified Anti-Mouse CD161/NK1.1 Antibody [PK136]
SKU:AGEL0479
Size:50µg, 500µg, 1mg
Clone No:PK136
Synonyms:Killer cell lectin-like receptor subfamily B member 1C;Klrb1c;CD161 antigen-like family member C;Ly-55c;CD161/NK1.1;NKR-P1.9;NKR-P1C;NKR-P1 40;CD161c;
Host Species:Mouse
Reactivity:Mouse
Application:FCM;Activ;Block;Depletion
Isotype:Mouse IgG2a, κ
Isotype Control:AF/LE Purified Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:None (AF/LE)
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P27814 P27812 Q99JB4
Gene ID:17059
Storage Buffer:0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:NK-1.1 surface antigen, also known as CD161b/CD161c and Ly-55, is encoded by the NKR-P1B/NKR-P1C gene. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers.

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