The ZW10 Polyclonal Antibody (CAB6328) is a valuable tool for researchers studying ZW10, a protein involved in chromosome segregation during cell division. This antibody, produced in rabbits, is highly specific to ZW10 and has been validated for use in Western blot applications. By binding to ZW10, this antibody enables researchers to detect and analyze the protein in various cell types, making it an ideal choice for studies in cell biology and cancer research.ZW10 is essential for the correct alignment and segregation of chromosomes during mitosis, making it a key player in maintaining genomic stability.
Dysregulation of ZW10 has been linked to chromosomal instability and tumorigenesis, highlighting its importance in cancer research. By studying the function of ZW10, researchers can gain insights into the mechanisms behind chromosome segregation errors and potentially develop targeted therapies for cancer treatment.
Product Name:
ZWINT Rabbit Polyclonal Antibody
SKU:
CAB6328
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-277 of human ZWINT (NP_008988.2).
This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
11130
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ZWINT antibody (CAB6328) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
