ZRSR2 Antibody (PACO48590)

SKU:

PACO48590

Product Type:

Antibody

Reactivity:

Human

Mouse

Host Species:

Rabbit

Isotype:

IgG

Applications:

ELISA

IHC

Antibody Type:

Polyclonal Antibody

Conjugation:

Unconjugated

Description

Description

DatasheetMSDS

ZRSR2 Antibody (PACO48590)

The ZRSR2 Polyclonal Antibody (PAC048590) is a valuable tool for researchers studying ZRSR2, a key protein involved in RNA splicing and gene regulation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to ZRSR2, this antibody allows for the detection and analysis of this important protein in a variety of cell types.ZRSR2, also known as Zinc finger CCCH domain-containing protein 11A, plays a crucial role in the splicing of RNA, which is essential for the regulation of gene expression.

Dysregulation of RNA splicing has been implicated in various diseases, including cancer and neurodegenerative disorders. Therefore, studying ZRSR2 and its functions can provide valuable insights into these diseases and potentially lead to the development of novel therapies.By utilizing the ZRSR2 Polyclonal Antibody in your research, you can uncover the role of ZRSR2 in RNA splicing and gene regulation, furthering our understanding of disease mechanisms and potentially identifying new therapeutic targets.

Background:

Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing.

Synonyms:

U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20) (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (U2AF35-related protein) (URP), ZRSR2, U2AF1-RS2 U2AF1L2 U2AF1RS2 URP

UniProt Protein Function:	ZRSR2: Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP- dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing.Protein type: RNA splicingChromosomal Location of Human Ortholog: Xp22.1Cellular Component: U12-dependent spliceosomeMolecular Function: pre-mRNA 3'-splice site binding; protein bindingBiological Process: nuclear mRNA splicing, via spliceosome; RNA splicing; spliceosome assembly
UniProt Protein Details:
NCBI Summary:	This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly. [provided by RefSeq, Jul 2008]
UniProt Code:	Q15696
NCBI GenInfo Identifier:	2833266
NCBI Gene ID:	8233
NCBI Accession:	Q15696.2
UniProt Secondary Accession:	Q15696,Q14D69
UniProt Related Accession:	Q15696
Molecular Weight:	58,045 Da
NCBI Full Name:	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2
NCBI Synonym Full Names:	zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
NCBI Official Symbol:	ZRSR2
NCBI Official Synonym Symbols:	URP; ZC3H22; U2AF1L2; U2AF1RS2; U2AF1-RS2
NCBI Protein Information:	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2
UniProt Protein Name:	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2
UniProt Synonym Protein Names:	CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2; Renal carcinoma antigen NY-REN-20; U2(RNU2) small nuclear RNA auxiliary factor 1-like 2; U2AF35-related protein; URP
Protein Family:	U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein
UniProt Gene Name:	ZRSR2
UniProt Entry Name:	U2AFM_HUMAN

ZRSR2P1 Antibody (PACO46498)

€359

Product Code:

PACO46498

Isotype:

IgG

Antibody Type:

Polyclonal Antibody

Immunofluorescence staining of MCF-7 cells with PACO64925 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). — Choose Options

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RIMS4 Antibody (PACO64925)

€319

Product Code:

PACO64925

Antibody Type:

Polyclonal Antibody

Isotype:

IgG

Western Blot<br />
Positive WB detected in: Mouse heart tissue,Mouse kidney tissue<br />
All lanes: ompF antibody at 1:2000<br />
Secondary<br />
Goat polyclonal to rabbit IgG at 1/50000 dilution<br />
Predicted band size: 57 kDa<br />
Observed band size: 57 kDa<br /> — Choose Options

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Ang4 Antibody (PACO64593)

€339

Product Code:

PACO64593

Antibody Type:

Polyclonal Antibody

Isotype:

IgG

Immunofluorescence staining of NIH/3T3 cells with PACO64869 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). — Choose Options

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OR13C8 Antibody (PACO64869)

€319

Product Code:

PACO64869

Antibody Type:

Polyclonal Antibody

Isotype:

IgG

Immunofluorescence staining of Hela cells with PACO64949 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). — Choose Options

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SIM1 Antibody (PACO64949)

€339

Product Code:

PACO64949

Antibody Type:

Polyclonal Antibody

Isotype:

IgG

Western Blot<br />
Positive WB detected in: Escherichia coli lysate<br />
All lanes: OTSB antibody at 1:2000<br />
Secondary<br />
Goat polyclonal to rabbit IgG at 1/50000 dilution<br />
Predicted band size: 30 kDa<br />
Observed band size: 30 kDa<br /> — Choose Options

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otsB Antibody (PACO64885)

€339

Product Code:

PACO64885

Antibody Type:

Polyclonal Antibody

Isotype:

IgG

IHC image of PACO64929 diluted at 1:300 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. — Choose Options

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RNF122 Antibody (PACO64929)

€319

Product Code:

PACO64929

Antibody Type:

Polyclonal Antibody

Isotype:

IgG

Immunofluorescence staining of SH-SY5Y cells with PACO64589-IF at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). — Choose Options

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AGO4 Antibody (PACO64589)

€319

Product Code:

PACO64589

Antibody Type:

Polyclonal Antibody

Isotype:

IgG

IHC image of PACO64729 diluted at 1:200 and staining in paraffin-embedded rat kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. — Choose Options

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Fn1 Antibody (PACO64729)

€339

Product Code:

PACO64729

Isotype:

IgG

Antibody Name:	ZRSR2 Antibody (PACO48590)
Antibody SKU:	PACO48590
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC, IF
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200
Species Reactivity:	Human, Mouse
Immunogen:	Recombinant Human U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 protein (191-372AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

ZRSR2 Antibody (PACO48590)

Description

ZRSR2 Antibody (PACO48590)

Overview

Properties

Product Images

Additional Information

Related Products

	Western Blot. Positive WB detected in: K562 whole cell lysate, HEK293 whole cell lysate, Mouse heart tissue. All lanes: ZRSR2 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 59 kDa. Observed band size: 59 kDa..
	Immunofluorescent analysis of HepG2 cells using PACO48590 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
	Immunohistochemistry of paraffin-embedded human testis tissue using PACO48590 at dilution of 1:100.

ZRSR2 Antibody (PACO48590)

Description

ZRSR2 Antibody (PACO48590)

Overview

Properties

Product Images

Additional Information

Related Products

Related Products

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