The ZNRF2 Polyclonal Antibody (PACO03661) is a valuable tool for research involving ZNRF2, a protein involved in the regulation of cell signaling pathways and protein degradation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically targeting the ZNRF2 protein, this antibody enables precise detection and analysis in various cell types, making it an ideal choice for studies in molecular biology and cancer research.
ZNRF2 is a critical regulator of the Wnt signaling pathway, which plays a crucial role in development, tissue homeostasis, and disease progression, including cancer. By modulating the activity of ZNRF2, researchers can gain insights into the mechanisms underlying these processes and potentially identify novel therapeutic targets for various diseases. The ZNRF2 Polyclonal Antibody provides a valuable tool for investigating the role of ZNRF2 in cellular processes and disease pathogenesis.
Antibody Name:
ZNRF2 Antibody
Antibody SKU:
PACO03661
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC, IF
Recommended Dilutions:
IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the C-terminal region of human ZNRF2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
ZNRF2; RNF202; E3 ubiquitin-protein ligase ZNRF2; Protein Ells2; RING finger protein 202; Zinc/RING finger protein 2
UniProt Protein Function:
ZNRF2: May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.Protein type: Ubiquitin ligase; EC 6.3.2.19; Ubiquitin conjugating system; EC 6.3.2.-; LigaseChromosomal Location of Human Ortholog: 7p14.3Cellular Component: cytoplasm; cytoplasmic vesicle membrane; cytosol; plasma membrane; protein complexMolecular Function: ubiquitin-protein ligase activityBiological Process: protein polyubiquitination
