The ZNRF1 Polyclonal Antibody (CAB15918) is a research tool designed to target the ZNRF1 protein, which plays a key role in regulating the Wnt signaling pathway. By inhibiting the activity of ZNRF1, researchers can investigate its impact on cellular processes such as cell proliferation, differentiation, and survival.Raised in rabbits, this antibody is highly specific and sensitive to human samples, making it a valuable tool for studies in molecular biology and cancer research. Validated for use in Western blot applications, this antibody allows for the detection and analysis of ZNRF1 protein levels in various cell types and tissues.
The ZNRF1 Polyclonal Antibody provides researchers with an opportunity to gain insights into the molecular mechanisms underlying Wnt signaling and its implications in cancer development and progression. Understanding the function of ZNRF1 can lead to the development of targeted therapies that manipulate this pathway for therapeutic purposes.
Product Name:
ZNRF1 Rabbit Polyclonal Antibody
SKU:
CAB15918
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human ZNRF1 (NP_115644.1).
This gene encodes an E3 ubiquitin-protein ligase that plays a role in neural-cell differentiation. Overexpression of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification, and in synaptic vessicle membranes in neurons.
Purification Method:
Affinity purification
Gene ID:
84937
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ZNRF1 Rabbit pAb (CAB15918) at 1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
