The ZNF513 Polyclonal Antibody (PAC031348) is an essential tool for researchers studying the zinc finger protein ZNF513. This antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting ZNF513 in human samples. Validated for Western blot applications, the ZNF513 antibody binds specifically to the ZNF513 protein, allowing for precise detection and analysis in various cell types.ZNF513 is a transcription factor that plays a key role in gene regulation and has been implicated in various cellular processes, including cell proliferation, differentiation, and development. Studies have shown that dysregulation of ZNF513 expression is associated with several diseases, making it a promising target for therapeutic interventions in conditions such as cancer, neurodegenerative disorders, and cardiovascular diseases.
By using the ZNF513 Polyclonal Antibody in their research, scientists can gain valuable insights into the function and regulation of ZNF513, helping to advance our understanding of its roles in health and disease. This antibody is a valuable tool for investigations in molecular biology, genetics, and biomedical research, providing a deeper understanding of ZNF513's mechanisms and potential therapeutic implications.
Antibody Name:
ZNF513 Antibody (PACO31348)
Antibody SKU:
PACO31348
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Zinc finger protein 513 protein (1-300AA)
Immunohistochemistry of paraffin-embedded human skin tissue using PACO31348 at dilution of 1:100.
Background:
Transcriptional regulator that plays a role in retinal development and maintenance.
Synonyms:
Zinc finger protein 513, ZNF513
UniProt Protein Function:
ZNF513: Transcriptional regulator that plays a role in retinal development and maintenance. Defects in ZNF513 are the cause of retinitis pigmentosa type 58 (RP58). A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Belongs to the krueppel C2H2-type zinc-finger protein family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: C2H2-type zinc finger proteinChromosomal Location of Human Ortholog: 2p23.3Cellular Component: nucleusMolecular Function: DNA binding; protein bindingBiological Process: retina development in camera-type eyeDisease: Retinitis Pigmentosa 58
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a possible transcriptional regulator involved in retinal development. Defects in this gene can be a cause of autosomal-recessive retinitis pigmentosa. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
