The ZNF420 Polyclonal Antibody (PAC062727) is essential for researchers studying the ZNF420 protein, a transcription factor known to play a role in gene regulation and chromatin organization. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the ZNF420 protein, researchers can accurately detect and analyze its expression in various cell types, making it an invaluable tool for studies in molecular biology and genetic disorders.ZNF420 is a key player in the intricate process of gene regulation, controlling the expression of important genes involved in development, differentiation, and disease.
Its involvement in chromatin organization also suggests a role in maintaining genomic stability and integrity. Understanding the function of ZNF420 is crucial for unraveling its impact on biological processes and its potential implications in diseases such as cancer, developmental disorders, and genetic abnormalities.Overall, the ZNF420 Polyclonal Antibody offers researchers a reliable and effective tool for investigating the functions and mechanisms of the ZNF420 protein, paving the way for advancements in molecular biology research and potential therapeutic interventions.
Antibody Name:
ZNF420 Antibody (PACO62727)
Antibody SKU:
PACO62727
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human Zinc finger protein 420 protein (50-256AA)
IHC image of PACO62727 diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
May be involved in transcriptional regulation.
Synonyms:
Zinc finger protein 420, ZNF420
UniProt Protein Function:
ZNF420: May be involved in transcriptional regulation.Protein type: Transcription factor; C2H2-type zinc finger proteinChromosomal Location of Human Ortholog: 19q13.12Cellular Component: nucleusMolecular Function: protein binding; DNA binding; metal ion binding; transcription factor activityBiological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a KRAB-type zinc finger protein that negatively-regulates p53-mediated apoptosis. Under stress conditions, the encoded protein is phosphorylated by ATM and dissociates from p53, which activates p53 and initiates apoptosis. [provided by RefSeq, Jul 2016]
