The ZNF420 Polyclonal Antibody (PAC022694) is a valuable tool for researchers studying ZNF420, a zinc finger protein involved in transcriptional regulation and gene expression. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the ZNF420 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in molecular biology and gene regulation.ZNF420 plays a critical role in controlling the expression of genes involved in various cellular processes, making it a key target for research in fields such as developmental biology, epigenetics, and oncology.
Understanding the function and regulation of ZNF420 is essential for unraveling its impact on normal cellular function and its potential role in disease development. Researchers can use this antibody to investigate the mechanisms by which ZNF420 influences gene expression and to explore its potential as a therapeutic target in various pathological conditions.
Antibody Name:
ZNF420 Antibody (PACO22694)
Antibody SKU:
PACO22694
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human ZNF420.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from K562 cells, using ZNF420 antibody.
Background:
May be involved in transcriptional regulation.
Synonyms:
Zinc finger protein 420; ZNF420;
UniProt Protein Function:
ZNF420: May be involved in transcriptional regulation.Protein type: Transcription factor; C2H2-type zinc finger proteinChromosomal Location of Human Ortholog: 19q13.12Cellular Component: nucleusMolecular Function: protein binding; DNA binding; metal ion binding; transcription factor activityBiological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a KRAB-type zinc finger protein that negatively-regulates p53-mediated apoptosis. Under stress conditions, the encoded protein is phosphorylated by ATM and dissociates from p53, which activates p53 and initiates apoptosis. [provided by RefSeq, Jul 2016]
