The ZNF420 Polyclonal Antibody (PAC020965) is a valuable tool for researchers studying the ZNF420 protein, a member of the zinc finger protein family known for its involvement in transcriptional regulation. This antibody, raised in rabbits, specifically targets human samples and is suitable for use in Western blot applications. By binding to the ZNF420 protein, researchers can accurately detect and analyze its expression in various cell types, making it an essential tool for studies in molecular biology and gene regulation.ZNF420 is a transcriptional regulator that plays a key role in controlling gene expression, making it an important target for research in developmental biology, cancer biology, and epigenetics.
Understanding the function of ZNF420 can provide valuable insights into how gene expression is regulated and how disruptions in this process can contribute to disease development. This antibody enables researchers to investigate the role of ZNF420 in various cellular processes, paving the way for the development of targeted therapies and potential diagnostic applications.
Antibody Name:
ZNF420 Antibody (PACO20965)
Antibody SKU:
PACO20965
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:10-1:50
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human ZNF420
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20965(ZNF420 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
May be involved in transcriptional regulation.
Synonyms:
zinc finger protein 420
UniProt Protein Function:
ZNF420: May be involved in transcriptional regulation.Protein type: Transcription factor; C2H2-type zinc finger proteinChromosomal Location of Human Ortholog: 19q13.12Cellular Component: nucleusMolecular Function: protein binding; DNA binding; metal ion binding; transcription factor activityBiological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a KRAB-type zinc finger protein that negatively-regulates p53-mediated apoptosis. Under stress conditions, the encoded protein is phosphorylated by ATM and dissociates from p53, which activates p53 and initiates apoptosis. [provided by RefSeq, Jul 2016]
