The ZNF420 Antibody (PAC020964) is a valuable tool for researchers studying the ZNF420 protein, a transcription factor involved in gene regulation and DNA binding. This polyclonal antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to ZNF420, this antibody allows for the detection and analysis of the protein in various cell types, making it ideal for studies in molecular biology and cancer research.ZNF420 plays a crucial role in regulating gene expression and controlling cellular processes, making it a key player in the development and progression of diseases such as cancer and genetic disorders.
Research into the function of ZNF420 can provide valuable insights into these conditions and help identify potential therapeutic targets for treatment. Understanding the molecular mechanisms controlled by ZNF420 is essential for advancing our knowledge of gene regulation and its implications in human health.
Antibody Name:
ZNF420 Antibody (PACO20964)
Antibody SKU:
PACO20964
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human ZNF420
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO20964(ZNF420 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20964(ZNF420 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
May be involved in transcriptional regulation.
Synonyms:
zinc finger protein 420
UniProt Protein Function:
ZNF420: May be involved in transcriptional regulation.Protein type: Transcription factor; C2H2-type zinc finger proteinChromosomal Location of Human Ortholog: 19q13.12Cellular Component: nucleusMolecular Function: protein binding; DNA binding; metal ion binding; transcription factor activityBiological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a KRAB-type zinc finger protein that negatively-regulates p53-mediated apoptosis. Under stress conditions, the encoded protein is phosphorylated by ATM and dissociates from p53, which activates p53 and initiates apoptosis. [provided by RefSeq, Jul 2016]
