The ZNF420 Polyclonal Antibody (PACO02509) is a valuable tool for researchers studying the ZNF420 protein, a transcription factor involved in gene regulation and cell differentiation. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards ZNF420 in human samples, making it suitable for use in various research applications, including Western blot analysis.ZNF420 is known for its role in controlling gene expression and influencing cellular processes such as cell growth and development. Research suggests that dysregulation of ZNF420 may be associated with certain diseases, making it a potential therapeutic target.
By using the ZNF420 Polyclonal Antibody, researchers can investigate the function and expression of ZNF420 in different cell types and disease states, providing insight into its potential role in cancer, developmental disorders, and other conditions. Overall, the ZNF420 Polyclonal Antibody is a valuable tool for studying the function and regulation of ZNF420, offering researchers the opportunity to deepen their understanding of this important transcription factor and its implications in various biological processes and disease mechanisms.
Antibody Name:
ZNF420 Antibody
Antibody SKU:
PACO02509
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the Internal region of human ZNF420.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
ZNF420; Zinc finger protein 420
UniProt Protein Function:
ZNF420: May be involved in transcriptional regulation.Protein type: Transcription factor; C2H2-type zinc finger proteinChromosomal Location of Human Ortholog: 19q13.12Cellular Component: nucleusMolecular Function: protein binding; DNA binding; metal ion binding; transcription factor activityBiological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a KRAB-type zinc finger protein that negatively-regulates p53-mediated apoptosis. Under stress conditions, the encoded protein is phosphorylated by ATM and dissociates from p53, which activates p53 and initiates apoptosis. [provided by RefSeq, Jul 2016]
