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ZNF397 Antibody (PACO01728)

SKU:
PACO01728
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$323
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Description

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ZNF397 Antibody (PACO01728)

The ZNF397 Polyclonal Antibody (PACO01728) is a powerful tool for researchers studying zinc finger protein 397 (ZNF397), a transcription factor involved in gene expression regulation. This antibody, produced in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications. By specifically binding to the ZNF397 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in molecular biology and gene regulation research.

ZNF397 is known to play a crucial role in the control of gene expression, impacting processes such as cell growth, differentiation, and development. Dysregulation of ZNF397 has been linked to various diseases, including cancer and neurological disorders, making it a promising target for therapeutic interventions. By studying the function of ZNF397 with this antibody, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new treatment strategies.

Antibody Name:ZNF397 Antibody
Antibody SKU:PACO01728
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human
Immunogen:synthesized peptide derived from the N-terminal region of human ZNF397.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:ZNF397; ZNF47; ZSCAN15; Zinc finger protein 397; Zinc finger and SCAN domain-containing protein 15; Zinc finger protein 47
UniProt Protein Function:ZNF397: Isoform 3 acts as a DNA-dependent transcriptional repressor. Belongs to the krueppel C2H2-type zinc-finger protein family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:DNA-binding; C2H2-type zinc finger protein; Transcription factor

Chromosomal Location of Human Ortholog: 18q12.2

Cellular Component: cytoplasm; nucleus

Molecular Function:metal ion binding; protein binding; sequence-specific DNA binding; transcription factor activity

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent

NCBI Summary:This gene encodes a protein with a N-terminal SCAN domain, and the longer isoform contains nine C2H2-type zinc finger repeats in the C-terminal domain. The protein localizes to centromeres during interphase and early prophase, and different isoforms can repress or activate transcription in transfection studies. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]
UniProt Code:Q8NF99
NCBI GenInfo Identifier:38258943
NCBI Gene ID:84307
NCBI Accession:Q8NF99.2
UniProt Secondary Accession:Q8NF99,Q9BRM2,
UniProt Related Accession:Q8NF99
Molecular Weight:24,141 Da
NCBI Full Name:Zinc finger protein 397
NCBI Synonym Full Names:zinc finger protein 397
NCBI Official Symbol:ZNF397  
NCBI Official Synonym Symbols:ZNF47; ZSCAN15  
NCBI Protein Information:zinc finger protein 397
UniProt Protein Name:Zinc finger protein 397
UniProt Synonym Protein Names:Zinc finger and SCAN domain-containing protein 15; Zinc finger protein 47
Protein Family:Zinc finger protein
UniProt Gene Name:ZNF397  
UniProt Entry Name:ZN397_HUMAN

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