The ZNF365 Polyclonal Antibody (PAC046694) is specifically designed for research involving the ZNF365 protein, a transcription factor that plays a key role in gene regulation and DNA repair mechanisms. This antibody, produced using rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot and immunohistochemistry applications. It binds specifically to the ZNF365 protein, enabling precise detection and analysis in various cell types, making it an ideal tool for studies in molecular biology and cancer research.
ZNF365, also known as ZAD-ZNF365 or ZNF385D, is involved in the regulation of gene expression and DNA damage repair processes, making it a crucial factor in maintaining genomic stability and preventing cancer development. Its function in these mechanisms highlights its importance as a potential target for research into cancer biology and therapeutic development. Understanding the role of ZNF365 in cellular processes is essential for advancing our knowledge of cancer biology and developing targeted therapies for cancer treatment.
Immunohistochemistry of paraffin-embedded human brain tissue using PACO46694 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO46694 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human glioma using PACO46694 at dilution of 1:100.
Synonyms:
Protein ZNF365 (DISC1-binding zinc-finger protein) (Protein su48), ZNF365, DBZ KIAA0844
UniProt Protein Function:
Involved in the regulation of neurogenesis. Negatively regulates neurite outgrowth (PubMed:17389905). Involved in the morphogenesis of basket cells in the somatosensory cortex during embryogenesis. Involved in the positive regulation of oligodendrocyte differentiation during postnatal growth. Involved in dendritic arborization, morphogenesis of spine density dendrite, and establishment of postsynaptic dendrite density in cortical pyramidal neurons (). Involved in homologous recombination (HR) repair pathway. Required for proper resolution of DNA double-strand breaks (DSBs) by HR. Is required for recovery of stalled replication forks, and directly contributes to genomic stability. Interacts with PARP1 and mediates MRE11-dependent DNA end resection during replication fork recovery (PubMed:23966166). Contributes to genomic stability by preventing telomere dysfunction (PubMed:23776040).
UniProt Protein Details:
NCBI Summary:
This gene encodes several isoforms which have different expression patterns and functions. Mutation in this gene is associated with uric acid nephrolithiasis (UAN). Alternatively spliced variants, encoding distinct proteins, have been identified. [provided by RefSeq, May 2010]
