The ZNF365 Polyclonal Antibody (PAC020956) is a valuable tool for research involving ZNF365, a protein involved in DNA repair and genome stability. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the ZNF365 protein, this antibody enables detection and analysis in a variety of cell types, making it ideal for studies in genetics, cancer research, and DNA damage response mechanisms.ZNF365, also known as ZIN, plays a crucial role in maintaining genomic integrity by facilitating DNA double-strand break repair through homologous recombination.
Dysregulation of ZNF365 has been implicated in various cancer types and genetic disorders, highlighting its importance in cellular functions. Research into the function and regulation of ZNF365 is essential for further understanding its role in disease development and potential therapeutic interventions targeting DNA repair pathways.By utilizing the ZNF365 Polyclonal Antibody, researchers can delve deeper into the mechanisms underlying DNA repair processes and genomic instability, ultimately advancing our knowledge of disease mechanisms and potential treatment strategies.
Antibody Name:
ZNF365 Antibody (PACO20956)
Antibody SKU:
PACO20956
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:2000, WB:1:200-1:1000
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human ZNF365
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 12%SDS-PAGE, Lysate: 40 µg, Lane: Human liver cancer tissue, Primary antibody: PACO20956(ZNF365 Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds.
Background:
This gene encodes several isoforms which have different expression patterns and functions. Mutation in this gene is associated with uric acid, nephrolithiasis (UAN). Alternatively spliced variants, encoding distinct proteins, have been identified.
Synonyms:
zinc finger protein 365
UniProt Protein Function:
ZNF365: several isoforms which have different expression patterns and functions. Mutation in this gene is associated with uric acid nephrolithiasis (UAN). Alternatively spliced variants, encoding distinct proteins, have been identified. [provided by RefSeq, May 2010]Protein type: Unknown functionChromosomal Location of Human Ortholog: 10q21.2Molecular Function: protein bindingDisease: Nephrolithiasis, Uric Acid, Susceptibility To
UniProt Protein Details:
NCBI Summary:
This gene encodes several isoforms which have different expression patterns and functions. Mutation in this gene is associated with uric acid nephrolithiasis (UAN). Alternatively spliced variants, encoding distinct proteins, have been identified. [provided by RefSeq, May 2010]
