ZNF335 Antibody (PACO49082)
- SKU:
- PACO49082
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
ZNF335 Antibody (PACO49082)
The ZNF335 Polyclonal Antibody (PAC049082) is a vital tool for researchers studying the ZNF335 protein, a key regulator of gene expression and transcription. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting ZNF335 in human samples and is validated for Western blot applications. By binding to ZNF335, this antibody enables accurate detection and analysis of this important protein in a variety of cell types, making it an excellent choice for studies in genetics, epigenetics, and chromatin remodeling.
ZNF335, also known as zinc finger protein 335, plays a crucial role in controlling gene expression and chromatin organization, impacting cellular processes like development, differentiation, and DNA repair. Dysregulation of ZNF335 has been implicated in various diseases, including developmental disorders, cancer, and neurological conditions. By investigating the function of ZNF335, researchers can gain insights into the molecular mechanisms underlying these disorders and potentially identify novel therapeutic targets for intervention.
| Antibody Name: | ZNF335 Antibody (PACO49082) |
| Antibody SKU: | PACO49082 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Zinc finger protein 335 protein (672-909AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: MCF-7 whole cell lysate. All lanes: ZNF335 antibody at 3.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 145, 130 kDa. Observed band size: 145, 130 kDa.. |
| Background: | Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation. |
| Synonyms: | Zinc finger protein 335 (NRC-interacting factor 1) (NIF-1), ZNF335 |
| UniProt Protein Function: | ZNF335: a probable transcriptional regulator of the krueppel C2H2-type zinc-finger protein family. |
| UniProt Protein Details: | Protein type:C2H2-type zinc finger protein; DNA-binding; Transcription regulation; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 20q13.12 Cellular Component: histone methyltransferase complex; nucleus Molecular Function:protein binding; metal ion binding Biological Process: positive regulation of neuroblast proliferation; positive regulation of neurogenesis; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of lymphocyte proliferation; in utero embryonic development; brain morphogenesis; regulation of histone H3-K4 methylation; brain development; regulation of gene expression, epigenetic; neurite morphogenesis; cerebral cortex neuron differentiation Disease: Microcephaly 10, Primary, Autosomal Recessive |
| NCBI Summary: | The protein encoded by this gene enhances transcriptional activation by ligand-bound nuclear hormone receptors. However, it does this not by direct interaction with the receptor, but by direct interaction with the nuclear hormone receptor transcriptional coactivator NRC. The encoded protein may function by altering local chromatin structure. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9H4Z2 |
| NCBI GenInfo Identifier: | 11560152 |
| NCBI Gene ID: | 63925 |
| NCBI Accession: | NP_071378.1 |
| UniProt Secondary Accession: | Q9H4Z2,Q548D0, Q9H684, B4DLG7, |
| UniProt Related Accession: | Q9H4Z2 |
| Molecular Weight: | 129,615 Da |
| NCBI Full Name: | zinc finger protein 335 |
| NCBI Synonym Full Names: | zinc finger protein 335 |
| NCBI Official Symbol: | ZNF335Â Â |
| NCBI Official Synonym Symbols: | NIF1; NIF2; NIF-1; MCPH10Â Â |
| NCBI Protein Information: | zinc finger protein 335 |
| UniProt Protein Name: | Zinc finger protein 335 |
| UniProt Synonym Protein Names: | NRC-interacting factor 1; NIF-1 |
| Protein Family: | Mitosis inhibitor |
| UniProt Gene Name: | ZNF335Â Â |
| UniProt Entry Name: | ZN335_HUMAN |
| ELISA Kits |
| Human Zinc finger protein 335 / ZNF335 ELISA Kit |
| Human Zinc finger protein 335 (ZNF335) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
Mouse Zinc finger protein 335 (Znf335) ELISA Kit (MOEB0737)
Human Zinc finger protein 335 / ZNF335 ELISA Kit
Rat Zinc finger protein 335 (Znf335) ELISA Kit (RTEB0563)
Human Zinc finger protein 335 (ZNF335) ELISA Kit (HUEB0970)
