The ZNF274 Antibody (PACO39590) is a key tool for researchers studying the zinc finger protein ZNF274, which plays a crucial role in gene regulation and transcriptional repression. This polyclonal antibody, produced through rabbit immunization, is highly specific to human samples and has been rigorously validated for Western blotting applications.ZNF274 is a transcriptional repressor that helps control gene expression by binding to specific DNA sequences and interacting with other proteins involved in chromatin remodeling. Dysregulation of ZNF274 has been implicated in various diseases, including cancer and developmental disorders, making it a promising target for therapeutic interventions.
By using the ZNF274 Antibody, researchers can accurately detect and analyze ZNF274 protein levels in different cell types, shedding light on its function and potential implications in disease processes. This antibody is a valuable tool for studies in molecular biology, oncology, and developmental biology, providing crucial insights into the regulatory mechanisms of gene expression. Unlock the mysteries of gene regulation with the ZNF274 Antibody for cutting-edge research applications.
Antibody Name:
ZNF274 Antibody (PACO39590)
Antibody SKU:
PACO39590
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Neurotrophin receptor-interacting factor homolog protein (1-320AA)
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO39590 at dilution of 1:100.
Background:
Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression.
Synonyms:
Neurotrophin receptor-interacting factor homolog (Zinc finger protein 274) (Zinc finger protein HFB101) (Zinc finger protein with KRAB and SCAN domains 19) (Zinc finger protein zfp2) (Zf2), ZNF274, ZKSCAN19
UniProt Protein Function:
ZNF274: Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin- modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. Belongs to the krueppel C2H2-type zinc-finger protein family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Nucleolus; DNA-binding; C2H2-type zinc finger protein; Transcription factorChromosomal Location of Human Ortholog: 19qterCellular Component: centrosome; nucleusMolecular Function: neurotrophin p75 receptor binding; protein binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor activityBiological Process: regulation of transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals. [provided by RefSeq, Jul 2008]
