The ZNF148 Polyclonal Antibody (CAB7001) is a valuable tool for researchers studying ZNF148, a zinc finger protein involved in gene regulation and DNA binding. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the ZNF148 protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for investigations in molecular biology and cancer research.ZNF148, also known as ZBP-89, plays a crucial role in regulating gene expression and controlling cellular processes such as proliferation, differentiation, and apoptosis.
Its involvement in transcriptional regulation makes it a key player in the development and progression of diseases like cancer and metabolic disorders. Research on ZNF148 is essential for uncovering its molecular mechanisms and potential therapeutic applications in targeted therapies.By utilizing the ZNF148 Polyclonal Antibody, researchers can delve deeper into the functions and interactions of ZNF148 in cellular pathways, paving the way for advancements in understanding disease mechanisms and developing novel treatments.
Product Name:
ZNF148 Rabbit Polyclonal Antibody
SKU:
CAB7001
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 690-794 of human ZNF148 (NP_068799.2).
The protein encoded by this gene is a member of the Kruppel family of zinc finger DNA binding proteins. The encoded protein activates transcription of the T-cell receptor and intestinal alkaline phosphatase genes but represses transcription of the ornithine decarboxylase, vimentin, gastrin, stomelysin, and enolase genes. Increased expression of this gene results in decreased patient survival rates from colorectal cancer, while mutations in this gene have been associated with global developmental delay, hypoplastic corpus callosum, and dysmorphic facies.
Purification Method:
Affinity purification
Gene ID:
7707
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ZNF148 Rabbit pAb (CAB7001) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
