The ZNF106 Polyclonal Antibody (PAC020966) is a valuable tool for researchers studying ZNF106, a zinc finger protein involved in various cellular processes. This antibody, produced in rabbits, shows high reactivity with human samples and is suitable for Western blot applications. By binding to the ZNF106 protein, this antibody allows for the detection and analysis of ZNF106 in different cell types, making it an ideal choice for studies in molecular biology and cell biology.ZNF106 is known to play a crucial role in gene regulation, DNA binding, and RNA processing, making it a key player in transcriptional control and cellular function.
Its involvement in these processes suggests its potential relevance in various disease states, including cancer, developmental disorders, and neurodegenerative diseases. Understanding the function and regulation of ZNF106 could provide valuable insights into the mechanisms underlying these conditions and may uncover new therapeutic targets for intervention.
Antibody Name:
ZNF106 Antibody (PACO20966)
Antibody SKU:
PACO20966
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:20-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human ZNF106
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20966(ZNF106 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20966(ZNF106 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Kr¼ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZFP106 (Zinc finger protein 106), also known as zinc finger protein 474, is a 1883 amino acid, human homolog of the mouse Zfp106 protein and is a member of the Kr¼ppel C2H2-type zinc-finger family. Localized to the nucleus, ZFP106 contains two C2H2-type zinc fingers and is thought to be involved in transcriptional regulation.
Synonyms:
zinc finger protein 106
UniProt Protein Function:
ZFP106: a protein with six WD40 domains and a zinc-finger domain. May be involved in growth related metabolism. A region of ZFP106 is identical to a 600-amino acid sequence implicated in the insulin receptor signaling pathway. Regulated by NRF-1 and myogenin, and expressed in brown fat, developing brain, and striated muscle.Protein type: C2H2-type zinc finger protein; Nucleolus; Adaptor/scaffoldChromosomal Location of Human Ortholog: 15q15.1Cellular Component: membrane; nucleolus; cytosolMolecular Function: opioid peptide activity; metal ion binding; SH3 domain bindingBiological Process: insulin receptor signaling pathway
