The ZMPSTE24 Rabbit Polyclonal Antibody (CAB18593) is a valuable tool for researchers studying ZMPSTE24, a crucial enzyme involved in the processing of a key protein component in the nuclear membrane. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the ZMPSTE24 protein, this antibody enables accurate detection and analysis in a variety of cell types.ZMPSTE24 is essential for maintaining the structural integrity of the nuclear membrane and defects in this enzyme have been linked to progeria, a rare genetic disorder characterized by accelerated aging.
Research into ZMPSTE24 is important for understanding the molecular mechanisms underlying this condition and may lead to potential therapeutic targets. By investigating the function of ZMPSTE24, researchers can gain valuable insights into nuclear membrane biology and its implications in aging and age-related diseases.
Product Name:
ZMPSTE24 Rabbit Polyclonal Antibody
SKU:
CAB18593
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human ZMPSTE24 (NP_005848.2).
This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy.
Purification Method:
Affinity purification
Gene ID:
10269
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from SKOV3 cells, using ZMPSTE24 Rabbit pAb (CAB18593) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
