The ZMIZ1 Polyclonal Antibody (PAC020336) is a valuable tool for researchers studying the role of ZMIZ1 in gene regulation and cancer development. This antibody, raised in rabbits, is highly specific and sensitive for detecting ZMIZ1 protein in human samples, making it suitable for use in Western blot applications.ZMIZ1 is a transcription coactivator that plays a crucial role in regulating gene expression and cell growth. Dysregulation of ZMIZ1 has been associated with various types of cancer, making it a promising target for cancer research. By using the ZMIZ1 Polyclonal Antibody, researchers can accurately assess the expression levels of ZMIZ1 in different cell types and conditions, providing valuable insights into its function and potential therapeutic implications.
This antibody is a reliable tool for investigating the molecular mechanisms underlying cancer development and progression, as well as identifying potential targets for novel therapeutic strategies. Its high specificity and sensitivity make it an essential component of any research project focused on understanding the role of ZMIZ1 in cancer biology.
Gel: 6%SDS-PAGE, Lysate: 40 µg, Lane: 293T cells, Primary antibody: PACO20336(ZMIZ1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20336(ZMIZ1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia.
Synonyms:
zinc finger, MIZ-type containing 1
UniProt Protein Function:
RAI17: Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressorChromosomal Location of Human Ortholog: 10q22.3Cellular Component: intracellular membrane-bound organelle; nucleoplasm
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Mar 2010]
