The ZMIZ1 Polyclonal Antibody (PAC020335) is a valuable tool for researchers studying the ZMIZ1 protein, a key player in various cellular processes such as gene transcription and DNA repair. This antibody, derived from rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By specifically binding to ZMIZ1, researchers can detect and analyze this protein in a variety of cell types, making it an essential tool for studies in molecular biology and cancer research.
ZMIZ1, also known as zinc finger MIZ domain-containing protein 1, is known to interact with various transcription factors and co-regulators, influencing gene expression and cellular functions. Its involvement in DNA damage response and chromatin remodeling makes it a promising target for investigating diseases such as cancer and genetic disorders. Understanding the roles of ZMIZ1 in these pathways is crucial for developing targeted therapies and advancing our knowledge of cellular processes.
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20335(ZMIZ1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 6%SDS-PAGE, Lysate: 40 µg, Lane: Skov3 cells, Primary antibody: PACO20335(ZMIZ1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes.
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20335(ZMIZ1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia.
Synonyms:
zinc finger, MIZ-type containing 1
UniProt Protein Function:
RAI17: Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressorChromosomal Location of Human Ortholog: 10q22.3Cellular Component: intracellular membrane-bound organelle; nucleoplasm
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Mar 2010]
