The ZIM2 Polyclonal Antibody (PAC061738) is a valuable tool for researchers studying ZIM2, a protein involved in various cellular processes. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By targeting the ZIM2 protein, this antibody allows for the detection and analysis of ZIM2 in different cell types, making it ideal for research in molecular biology, cell signaling, and disease mechanisms.
ZIM2, also known as ZIM2 zinc finger protein, is known to play a role in gene regulation and may be implicated in developmental processes and cancer progression. Understanding the function and regulation of ZIM2 is essential for uncovering its significance in health and disease. By using the ZIM2 Polyclonal Antibody, researchers can further explore the role of ZIM2 in cellular pathways and potentially identify new therapeutic targets for various conditions.
Antibody Name:
ZIM2 Antibody (PACO61738)
Antibody SKU:
PACO61738
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human Zinc finger imprinted 2 protein (1-124AA)
IHC image of PACO61738 diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of PACO61738 diluted at 1:300 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
May be involved in transcriptional regulation.
Synonyms:
Zinc finger imprinted 2 (Zinc finger protein 656), ZIM2, ZNF656
UniProt Protein Function:
ZIM2: May be involved in transcriptional regulation. Belongs to the krueppel C2H2-type zinc-finger protein family.Protein type: C2H2-type zinc finger proteinChromosomal Location of Human Ortholog: 19q13.4Molecular Function: transcription factor activityBiological Process: regulation of transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
In human, ZIM2 and PEG3 (GeneID:5178) are two distinct genes that share a set of 5' exons and have a common promoter, and both genes are paternally expressed. Alternative splicing events connect the shared exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. This is in contrast to mouse and cow, where ZIM2 and PEG3 genes do not share exons in common, and the imprinting status of ZIM2 is also not conserved amongst mammals. Additional 5' alternatively spliced transcripts encoding the same protein have been found for the human ZIM2 gene. [provided by RefSeq, Oct 2010]