The ZIC5 Polyclonal Antibody (PACO57380) is a valuable tool for researchers studying the ZIC5 protein, a transcription factor involved in embryonic development and cell differentiation. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the ZIC5 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential tool for studies in developmental biology and cancer research.
ZIC5 is known for its role in regulating gene expression and cellular processes during early development, making it a key player in embryogenesis and tissue formation. Its involvement in various signaling pathways and developmental programs makes it a promising target for research into developmental disorders, genetic diseases, and cancer. By uncovering the mechanisms by which ZIC5 functions, researchers can gain insights into disease pathways and potentially identify new therapeutic targets for intervention.
Antibody Name:
ZIC5 Antibody (PACO57380)
Antibody SKU:
PACO57380
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human Zinc finger protein ZIC 5 protein (217-276AA)
IHC image of PACO57380 diluted at 1:200 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA (By similarity).
Synonyms:
Zinc finger protein ZIC 5 (Zinc finger protein of the cerebellum 5), ZIC5
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008]
