ZIC4 Antibody (PACO13668)
- SKU:
- PACO13668
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
ZIC4 Antibody (PACO13668)
The ZIC4 Polyclonal Antibody (PAC013668) is a valuable tool for researchers studying the ZIC4 protein, a transcription factor involved in neural development and disease. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it suitable for use in Western blot applications. By binding specifically to ZIC4, this antibody enables accurate detection and analysis of the protein in various cell types, offering insights into its function and potential roles in neurodevelopmental disorders and cancer.
ZIC4 is a key regulator of gene expression in the nervous system, playing a critical role in neuronal differentiation and patterning. Dysregulation of ZIC4 has been implicated in neurological conditions such as autism spectrum disorders and brain tumors, highlighting its importance in neural development and disease pathology. By investigating the functions of ZIC4, researchers can gain valuable insights into the molecular mechanisms underlying these disorders and identify potential therapeutic targets for intervention.
| Antibody Name: | ZIC4 Antibody (PACO13668) |
| Antibody SKU: | PACO13668 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Human ZIC4-Specific |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | Zic family member 4;ZIC4;FLJ42609;FLJ45833 ; |
| UniProt Protein Function: | ZIC4: Binds to DNA. Belongs to the GLI C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:C2H2-type zinc finger protein Chromosomal Location of Human Ortholog: 3q24 Cellular Component: nucleus Molecular Function:DNA binding |
| NCBI Summary: | This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development, and have been associated with X-linked visceral heterotaxy and holoprosencephaly type 5. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 1, a related family member on chromosome 3. Heterozygous deletion of these linked genes is involved in Dandy-Walker malformation, which is a congenital cerebellar malformation. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Dec 2009] |
| UniProt Code: | Q8N9L1 |
| NCBI GenInfo Identifier: | 85700440 |
| NCBI Gene ID: | 84107 |
| NCBI Accession: | Q8N9L1.3 |
| UniProt Secondary Accession: | Q8N9L1,Q4G157, Q9BZ94, A0AVA2, B2RMQ8, B4DF89, B7Z2L2 C9J7D5, J3KQG1, |
| UniProt Related Accession: | Q8N9L1 |
| Molecular Weight: | 40,641 Da |
| NCBI Full Name: | Zinc finger protein ZIC 4 |
| NCBI Synonym Full Names: | Zic family member 4 |
| NCBI Official Symbol: | ZIC4Â Â |
| NCBI Protein Information: | zinc finger protein ZIC 4 |
| UniProt Protein Name: | Zinc finger protein ZIC 4 |
| UniProt Synonym Protein Names: | Zinc finger protein of the cerebellum 4 |
| Protein Family: | Zinc finger protein |
| UniProt Gene Name: | ZIC4Â Â |
| UniProt Entry Name: | ZIC4_HUMAN |
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