The ZIC3 Polyclonal Antibody (CAB9476) is a valuable tool for researchers studying ZIC3, a transcription factor critical for embryonic development and implicated in various diseases, including congenital heart defects and neural tube defects. This antibody, raised in rabbits, boasts high reactivity with human samples and is validated for use in Western blot applications.ZIC3 plays a crucial role in regulating gene expression during early development, making it a key player in the formation of various organs and tissues. Dysregulation of ZIC3 has been linked to developmental abnormalities and diseases, highlighting its importance in biomedical research.
By specifically binding to the ZIC3 protein, this antibody enables accurate detection and analysis of ZIC3 expression in a variety of sample types, making it an essential tool for studies in developmental biology, genetics, and disease pathology. Understanding the function and regulation of ZIC3 opens up avenues for therapeutic interventions and potential treatments for disorders associated with ZIC3 dysfunction.
Product Name:
ZIC3 Rabbit Polyclonal Antibody
SKU:
CAB9476
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human ZIC3 (NP_003404.1).
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs.
Purification Method:
Affinity purification
Gene ID:
7547
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ZIC3 antibody (CAB9476) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
