The ZIC2 Polyclonal Antibody (CAB15736) is a cutting-edge tool for researchers studying ZIC2, a transcription factor involved in embryonic development and cell differentiation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards ZIC2 in human samples, making it ideal for Western blot applications.ZIC2 is known to play a crucial role in regulating gene expression and controlling various developmental processes, making it a key target for investigations in developmental biology and regenerative medicine. By using the ZIC2 Polyclonal Antibody, researchers can accurately detect and analyze ZIC2 expression in different cell types, aiding in the understanding of its functions and interactions with other proteins.
The versatility of the ZIC2 Polyclonal Antibody makes it a valuable asset for studies in neurobiology, stem cell research, and cancer biology, where dysregulation of ZIC2 expression has been implicated in various disease states. By exploring the mechanisms behind ZIC2 activity, scientists can uncover new insights into cellular processes and potentially identify novel therapeutic targets for a range of disorders.
Product Name:
ZIC2 Rabbit Polyclonal Antibody
SKU:
CAB15736
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ZIC2 (NP_009060.2).
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Expansion of an alanine repeat in the C-terminus of the encoded protein and other mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13.
Purification Method:
Affinity purification
Gene ID:
7546
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ZIC2 Rabbit pAb (CAB15736) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
