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ZIC1/ZIC2/ZIC3 Antibody (PACO05328)

SKU:
PACO05328
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
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Description

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ZIC1/ZIC2/ZIC3 Antibody (PACO05328)

The ZIC1/ZIC2/ZIC3 Polyclonal Antibody (PACO05328) is a valuable tool for researchers studying the ZIC family of transcription factors. This antibody, produced in rabbits, is highly specific for ZIC1, ZIC2, and ZIC3 proteins and is validated for use in various applications, including Western blotting and immunohistochemistry.The ZIC family of transcription factors plays a crucial role in the regulation of gene expression, cell differentiation, and development. By targeting ZIC1, ZIC2, and ZIC3 proteins, researchers can gain insights into the mechanisms underlying embryonic development, neural patterning, and disease pathogenesis.

This antibody is ideal for studies in developmental biology, neuroscience, and cancer research, where dysregulation of ZIC proteins has been implicated in various diseases. By enabling the detection and analysis of ZIC1, ZIC2, and ZIC3 proteins in different cell types and tissues, this antibody opens up new possibilities for understanding the roles of these transcription factors in health and disease.

Antibody Name:ZIC1/ZIC2/ZIC3 Antibody (PACO05328)
Antibody SKU:PACO05328
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human, Mouse
Immunogen:Synthesized peptide derived from the Internal region of human Zic1/2/3.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:ZIC1; ZIC; ZNF201; Zinc finger protein ZIC 1; Zinc finger protein 201; Zinc finger protein of the cerebellum 1; ZIC2; Zinc finger protein ZIC 2; Zinc finger protein of the cerebellum 2; ZIC3; ZNF203; Zinc finger protein ZIC 3; Zinc finger p
UniProt Protein Function:ZIC1: Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally- located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'- TGGGTGGTC-3'. Belongs to the GLI C2H2-type zinc-finger protein family.
UniProt Protein Details:

Protein type:DNA-binding; C2H2-type zinc finger protein; Transcription factor

Chromosomal Location of Human Ortholog: 3q24

Cellular Component: nucleoplasm; nucleus

Molecular Function:transcription factor activity

Biological Process: brain development; inner ear morphogenesis; pattern specification process; positive regulation of protein import into nucleus; positive regulation of transcription, DNA-dependent; regulation of smoothened signaling pathway

Disease: Craniosynostosis 6

NCBI Summary:This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q15915
NCBI GenInfo Identifier:209572702
NCBI Gene ID:7545
NCBI Accession:Q15915.2
UniProt Secondary Accession:Q15915,Q2M3N1,
UniProt Related Accession:Q15915
Molecular Weight:48,309 Da
NCBI Full Name:Zinc finger protein ZIC 1
NCBI Synonym Full Names:Zic family member 1
NCBI Official Symbol:ZIC1  
NCBI Official Synonym Symbols:ZIC; CRS6; ZNF201  
NCBI Protein Information:zinc finger protein ZIC 1
UniProt Protein Name:Zinc finger protein ZIC 1
UniProt Synonym Protein Names:Zinc finger protein 201; Zinc finger protein of the cerebellum 1
Protein Family:Zinc finger protein
UniProt Gene Name:ZIC1  
UniProt Entry Name:ZIC1_HUMAN

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