The ZIC1 Polyclonal Antibody (CAB17547) is a valuable tool for researchers studying Zic family proteins, specifically ZIC1, a transcription factor involved in embryonic development and cell differentiation. Raised in rabbits, this antibody is highly specific and reactive with human samples, making it ideal for use in Western blot applications. It binds specifically to the ZIC1 protein, enabling accurate detection and analysis in a variety of cell types.ZIC1 plays a critical role in regulating gene expression and cell fate determination, making it a key player in developmental processes.
Dysregulation of ZIC1 has been implicated in various diseases, including cancer and neural tube defects. Understanding the function of ZIC1 is essential for uncovering its role in these conditions and potentially identifying new therapeutic targets.Overall, the ZIC1 Polyclonal Antibody is a reliable tool for researchers investigating the mechanisms of gene regulation and cell differentiation in development and disease. Its specificity and sensitivity make it a valuable asset in studies aimed at unraveling the complexities of ZIC1 biology.
Product Name:
ZIC1 Rabbit Polyclonal Antibody
SKU:
CAB17547
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 120-210 of human ZIC1 (NP_003403.2).
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene.
Purification Method:
Affinity purification
Gene ID:
7545
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ZIC1 Rabbit pAb (CAB17547) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
