The ZFYVE27 Polyclonal Antibody (CAB15943) is a valuable tool for researchers studying ZFYVE27, a protein involved in autophagy and vesicular trafficking processes within cells. The antibody, generated in rabbits, exhibits high specificity and sensitivity towards ZFYVE27 in human samples, making it ideal for use in Western blot applications. By binding to the ZFYVE27 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an essential reagent for investigations in cell biology and molecular biology.ZFYVE27, also known as Protrudin, plays a crucial role in regulating the formation and transport of vesicles in cells, particularly in the context of autophagy and intracellular signaling pathways.
Dysfunction of ZFYVE27 has been implicated in various diseases, including neurodegenerative disorders and cancer. Research into the role of ZFYVE27 can provide valuable insights into mechanisms of disease pathology and potential therapeutic targets. This antibody is a valuable tool for scientists looking to further understand the functions of ZFYVE27 and its implications in health and disease.
Product Name:
ZFYVE27 Rabbit Polyclonal Antibody
SKU:
CAB15943
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 217-411 of human ZFYVE27 (NP_653189.3).
This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear.
Purification Method:
Affinity purification
Gene ID:
118813
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from DU145 cells, using ZFYVE27 Rabbit pAb (CAB15943) at 1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
