| UniProt Protein Function: | ZFYVE26: Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair. Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A. Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 14q24.1Cellular Component: centrosome; lysosomal membrane; midbodyMolecular Function: protein binding; metal ion binding; phosphatidylinositol 3-phosphate bindingBiological Process: cytokinesis; double-strand break repair via homologous recombinationDisease: Spastic Paraplegia 15, Autosomal Recessive |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008] |
| UniProt Code: | Q68DK2 |
| NCBI GenInfo Identifier: | 38202205 |
| NCBI Gene ID: | 23503 |
| NCBI Accession: | NP_056161.2 |
| UniProt Secondary Accession: | Q68DK2,O15035, Q68DT9, Q6AW90, Q6ZR50, Q7Z3A4, Q7Z3I1 Q8N4W7, B1B5Y3, B4E2U3 |
| UniProt Related Accession: | Q68DK2 |
| Molecular Weight: | 77,970 Da |
| NCBI Full Name: | zinc finger FYVE domain-containing protein 26 |
| NCBI Synonym Full Names: | zinc finger, FYVE domain containing 26 |
| NCBI Official Symbol: | ZFYVE26Â Â |
| NCBI Official Synonym Symbols: | SPG15; FYVE-CENTÂ Â |
| NCBI Protein Information: | zinc finger FYVE domain-containing protein 26; spastizin; FYVE domain-containing centrosomal protein |
| UniProt Protein Name: | Zinc finger FYVE domain-containing protein 26 |
| UniProt Synonym Protein Names: | FYVE domain-containing centrosomal protein; FYVE-CENT; Spastizin |
| Protein Family: | |
| UniProt Gene Name: | ZFYVE26Â Â |
| UniProt Entry Name: | ZFY26_HUMAN |
