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ZFYVE26 Antibody (PACO53110)

SKU:
PACO53110
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • ZFYVE26 Antibody PACO53110
  • ZFYVE26 Antibody PACO53110
€359

Description

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ZFYVE26 Antibody (PACO53110)

The ZFYVE26 Polyclonal Antibody (PAC053110) is a valuable tool for researchers studying ZFYVE26, a protein involved in regulating cellular processes such as endocytosis and autophagy. This antibody, raised in rabbits, offers high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the ZFYVE26 protein, this antibody enables precise detection and analysis in various cell types, making it an ideal choice for investigations in cell biology and molecular biology.

ZFYVE26, also known as SPG15, plays a crucial role in maintaining cellular homeostasis by facilitating the transport of molecules within cells and regulating intracellular trafficking pathways. Dysregulation of ZFYVE26 has been associated with neurodegenerative diseases, making it a promising target for research in the field of neuroscience. Understanding the functions of ZFYVE26 is essential for uncovering its role in disease pathogenesis and developing potential therapeutic interventions.

Antibody Name:ZFYVE26 Antibody (PACO53110)
Antibody SKU:PACO53110
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC, IF
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Zinc finger FYVE domain-containing protein 26 protein (2306-2473AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunohistochemistry of paraffin-embedded human brain tissue using PACO53110 at dilution of 1:100.
Product ImageImmunofluorescent analysis of HepG2 cells using PACO53110 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair.
Synonyms:Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin), ZFYVE26, KIAA0321
UniProt Protein Function:ZFYVE26: Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair. Interacts with AP5Z1, AP5B1, AP5S1 and SPG11. Interacts with TTC19 and KIF13A. Strongest expression in the adrenal gland, bone marrow, adult brain, fetal brain, lung, placenta, prostate, skeletal muscle, testis, thymus, and retina. Intermediate levels are detected in other structures, including the spinal cord. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 14q24.1Cellular Component: centrosome; lysosomal membrane; midbodyMolecular Function: protein binding; metal ion binding; phosphatidylinositol 3-phosphate bindingBiological Process: cytokinesis; double-strand break repair via homologous recombinationDisease: Spastic Paraplegia 15, Autosomal Recessive
UniProt Protein Details:
NCBI Summary:This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008]
UniProt Code:Q68DK2
NCBI GenInfo Identifier:38202205
NCBI Gene ID:23503
NCBI Accession:NP_056161.2
UniProt Secondary Accession:Q68DK2,O15035, Q68DT9, Q6AW90, Q6ZR50, Q7Z3A4, Q7Z3I1 Q8N4W7, B1B5Y3, B4E2U3
UniProt Related Accession:Q68DK2
Molecular Weight:77,970 Da
NCBI Full Name:zinc finger FYVE domain-containing protein 26
NCBI Synonym Full Names:zinc finger, FYVE domain containing 26
NCBI Official Symbol:ZFYVE26  
NCBI Official Synonym Symbols:SPG15; FYVE-CENT  
NCBI Protein Information:zinc finger FYVE domain-containing protein 26; spastizin; FYVE domain-containing centrosomal protein
UniProt Protein Name:Zinc finger FYVE domain-containing protein 26
UniProt Synonym Protein Names:FYVE domain-containing centrosomal protein; FYVE-CENT; Spastizin
Protein Family:
UniProt Gene Name:ZFYVE26  
UniProt Entry Name:ZFY26_HUMAN
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