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ZFYVE19 Antibody (PACO23501)

SKU:
PACO23501
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • ZFYVE19 Antibody PACO23501
  • ZFYVE19 Antibody PACO23501
€419
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Description

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ZFYVE19 Antibody (PACO23501)

The ZFYVE19 Polyclonal Antibody (PAC023501) is a valuable tool for researchers studying ZFYVE19, a protein involved in endosomal trafficking and autophagy regulation. This antibody, produced in rabbits, demonstrates high specificity for human samples and is validated for use in Western blot experiments. By targeting the ZFYVE19 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential asset for studies in cell biology and molecular biology.

ZFYVE19, also known as Protrudin, plays a crucial role in intracellular vesicle trafficking and organelle biogenesis, making it a key player in cellular homeostasis and autophagy regulation. Its involvement in these processes suggests potential implications in diseases related to aberrant autophagy, such as neurodegenerative disorders and metabolic diseases. Understanding the function of ZFYVE19 is vital for uncovering its potential as a therapeutic target for such conditions.

Antibody Name:ZFYVE19 Antibody (PACO23501)
Antibody SKU:PACO23501
Size:100ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100
Species Reactivity:Human
Immunogen:Synthesized peptide derived from internal of human ZFYVE19.
Form:Liquid
Storage Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot analysis of extracts from HT-29 cells, using ZFYVE19 antibody.
Product ImageImmunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using ZFYVE19 antibody.
Background:Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission.
Synonyms:MLL partner containing FYVE domain; MPFYVE; ZFY19; Zinc finger FYVE domain-containing protein 19;
UniProt Protein Function:ZFYVE19: A chromosomal aberration involving ZFYVE19 is associated with acute myeloblastic leukemia (AML). Translocation t(11;15)(q23;q14) with MLL/HRX. 3 isoforms of the human protein are produced by alternative splicing.Protein type: OncoproteinChromosomal Location of Human Ortholog: 15q15.1Cellular Component: centrosome; cleavage furrow; cytoplasm; midbodyMolecular Function: phosphatidylinositol 3-phosphate binding; protein binding; zinc ion bindingBiological Process: abscission; cell cycle; cell division; negative regulation of cytokinesis
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q96K21
NCBI GenInfo Identifier:296453076
NCBI Gene ID:84936
NCBI Accession:Q96K21.3
UniProt Secondary Accession:Q96K21,Q86WC2, Q8WU96, B3KVB2, C9JNF4, H3BUF9
UniProt Related Accession:Q96K21
Molecular Weight:32,963 Da
NCBI Full Name:Abscission/NoCut checkpoint regulator
NCBI Synonym Full Names:zinc finger FYVE-type containing 19
NCBI Official Symbol:ZFYVE19  
NCBI Official Synonym Symbols:ANCHR; MPFYVE  
NCBI Protein Information:abscission/NoCut checkpoint regulator
UniProt Protein Name:Abscission/NoCut checkpoint regulator
UniProt Synonym Protein Names:MLL partner containing FYVE domain; Zinc finger FYVE domain-containing protein 19
Protein Family:Abscission/NoCut checkpoint regulator
UniProt Gene Name:ZFYVE19  
UniProt Entry Name:ANCHR_HUMAN
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ZFYVE19 Antibody (PACO01720)
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