The ZFYVE19 Antibody (PAC01720) is a valuable tool for researchers studying ZFYVE19, a protein involved in autophagy and endosomal trafficking processes. This polyclonal antibody, produced in rabbits, is highly specific for human samples and is validated for use in various applications, including Western blotting and immunofluorescence.ZFYVE19, also known as FYCO1, plays a crucial role in the autophagy pathway by facilitating the maturation of autophagosomes and promoting their fusion with lysosomes.
Dysregulation of ZFYVE19 has been implicated in various diseases, including neurodegenerative disorders and cancer. By targeting ZFYVE19 with this antibody, researchers can investigate its role in these disease processes and potentially uncover new therapeutic targets.Overall, the ZFYVE19 Antibody (PAC01720) is a reliable tool for studying autophagy and endosomal trafficking mechanisms, with the potential to advance our understanding of disease pathology and identify novel therapeutic strategies.
Antibody Name:
ZFYVE19 Antibody
Antibody SKU:
PACO01720
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human ZFYVE19.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ZFYVE19: A chromosomal aberration involving ZFYVE19 is associated with acute myeloblastic leukemia (AML). Translocation t(11;15)(q23;q14) with MLL/HRX. 3 isoforms of the human protein are produced by alternative splicing.Protein type: OncoproteinChromosomal Location of Human Ortholog: 15q15.1Cellular Component: centrosome; cleavage furrow; cytoplasm; midbodyMolecular Function: phosphatidylinositol 3-phosphate binding; protein binding; zinc ion bindingBiological Process: abscission; cell cycle; cell division; negative regulation of cytokinesis
