The ZFPM2 Polyclonal Antibody (CAB9868) is a valuable tool for researchers studying ZFPM2, a transcription factor known for its role in development and cell differentiation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the ZFPM2 protein, researchers can effectively detect and analyze its expression in various cell types, making it a versatile tool for studies in developmental biology and disease research.ZFPM2, also called Fog2, is critical for normal heart and lung development, as well as for the regulation of gene expression during these processes.
Dysregulation of ZFPM2 has been linked to congenital heart defects and other developmental disorders. Therefore, understanding the function of ZFPM2 is essential for deciphering the molecular mechanisms underlying these conditions and developing potential therapeutic interventions.Overall, the ZFPM2 Polyclonal Antibody (CAB9868) offers researchers a reliable means to investigate the role of ZFPM2 in development and disease, paving the way for new insights and potential treatment strategies in the fields of developmental biology and medicine.
Product Name:
ZFPM2 Rabbit Polyclonal Antibody
SKU:
CAB9868
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 982-1151 of human ZFPM2 (NP_036214.2).
The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence.
Purification Method:
Affinity purification
Gene ID:
23414
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ZFPM2 antibody (CAB9868) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 40s.
