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ZFP36L2 Antibody (PACO55838)

SKU:
PACO55838
Product Type:
Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$407

Description

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ZFP36L2 Antibody (PACO55838)

The ZFP36L2 Antibody (PACO55838) is a valuable tool for researchers studying the zinc finger protein ZFP36L2, a key player in post-transcriptional gene regulation. This polyclonal antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.ZFP36L2, also known as TTP2, is involved in the degradation of specific mRNA targets, playing a critical role in processes such as cell proliferation, differentiation, and inflammation. By detecting and analyzing ZFP36L2 protein expression in various cell types, this antibody enables researchers to better understand its function in different biological contexts.

The importance of ZFP36L2 in gene regulation makes it a promising target for studies in areas such as immunology, cancer research, and developmental biology. By gaining insights into the role of ZFP36L2, researchers can potentially uncover new therapeutic targets for diseases characterized by dysregulated gene expression.

Antibody Name:ZFP36L2 Antibody (PACO55838)
Antibody SKU:PACO55838
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:Human, Rat
Immunogen:Recombinant Human mRNA decay activator protein ZFP36L2 protein (219-321AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern Blot. Positive WB detected in: Rat kidney tissue. All lanes: ZFP36L2 antibody at 2.6µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 52 kDa. Observed band size: 52 kDa.
Background:Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner. Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA.
Synonyms:mRNA decay activator protein ZFP36L2 (Butyrate response factor 2) (EGF-response factor 2) (ERF-2) (TPA-induced sequence 11d) (Zinc finger protein 36, C3H1 type-like 2) (ZFP36-like 2), ZFP36L2, BRF2 ERF2 RNF162C TIS11D
UniProt Protein Function:ZFP36L2: Probable regulatory protein involved in regulating the response to growth factors. RNA-binding protein that binds to 5'UUAUUUAUUU-3' core sequence. Binds to the class II AU-rich element (ARE) in the 3'-UTR of target mRNAs and promotes their deadenylation and degradation.
UniProt Protein Details:

Protein type:Transcription factor

Chromosomal Location of Human Ortholog: 2p22.3-p21

Cellular Component: cytoplasm; nucleus

Molecular Function:AU-rich element binding; transcription factor activity

Biological Process: cell proliferation; hemopoiesis; mRNA catabolic process; somatic stem cell division; somatic stem cell maintenance

NCBI Summary:This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008]
UniProt Code:P47974
NCBI GenInfo Identifier:146291085
NCBI Gene ID:678
NCBI Accession:P47974.3
UniProt Secondary Accession:P47974,Q53TB4, Q9BSJ3,
UniProt Related Accession:P47974
Molecular Weight:51,063 Da
NCBI Full Name:Zinc finger protein 36, C3H1 type-like 2
NCBI Synonym Full Names:ZFP36 ring finger protein like 2
NCBI Official Symbol:ZFP36L2  
NCBI Official Synonym Symbols:BRF2; ERF2; ERF-2; TIS11D; RNF162C  
NCBI Protein Information:zinc finger protein 36, C3H1 type-like 2
UniProt Protein Name:Zinc finger protein 36, C3H1 type-like 2
UniProt Synonym Protein Names:Butyrate response factor 2; EGF-response factor 2; ERF-2; Protein TIS11D
Protein Family:mRNA decay activator protein
UniProt Gene Name:ZFP36L2  
UniProt Entry Name:TISD_HUMAN
AntibodiesELISA Kits
ZFP36L2 Antibody (PACO01632)TISD Colorimetric Cell-Based ELISA
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