The ZFP36L2 Monoclonal Antibody (PACO20705) is a powerful tool for studying ZFP36L2, a key regulator of gene expression involved in post-transcriptional control of mRNA stability. This antibody, produced through monoclonal techniques, exhibits high specificity and sensitivity in detecting ZFP36L2 in human samples, making it ideal for use in Western blot and immunohistochemistry applications. By targeting the ZFP36L2 protein, researchers can explore its functions in various cellular processes, offering valuable insights into gene regulation and potential therapeutic targets.
ZFP36L2, also known as tristetraprolin-like 2, plays a crucial role in modulating mRNA turnover and translation, impacting the expression of genes involved in cellular growth, differentiation, and response to external stimuli. Its dysregulation has been linked to various diseases, including cancer, inflammatory disorders, and neurodegenerative conditions. By studying ZFP36L2 with this monoclonal antibody, researchers can deepen their understanding of its mechanisms and explore its potential as a target for therapeutic interventions in these pathological contexts.
Antibody Name:
ZFP36L2 Antibody (PACO20705)
Antibody SKU:
PACO20705
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human ZFP36L2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20705(ZFP36L2 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20705(ZFP36L2 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors.
Synonyms:
ZFP36 ring finger protein-like 2
UniProt Protein Function:
ZFP36L2: Probable regulatory protein involved in regulating the response to growth factors. RNA-binding protein that binds to 5'UUAUUUAUUU-3' core sequence. Binds to the class II AU-rich element (ARE) in the 3'-UTR of target mRNAs and promotes their deadenylation and degradation.
UniProt Protein Details:
Protein type:Transcription factor
Chromosomal Location of Human Ortholog: 2p22.3-p21
Cellular Component: cytoplasm; nucleus
Molecular Function:AU-rich element binding; transcription factor activity
This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008]
