The ZFP36L2 Polyclonal Antibody (PAC020704) is a versatile tool for research involving ZFP36L2, a zinc finger protein involved in post-transcriptional regulation of gene expression. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it suitable for various research applications.ZFP36L2 is known for its role in mRNA decay and turnover, affecting the stability of specific transcripts and influencing cellular processes like proliferation, differentiation, and immune response. By targeting ZFP36L2, researchers can investigate its impact on gene regulation in diverse cell types, providing valuable insights into developmental biology, cancer biology, and immune system function.
With its ability to detect and analyze ZFP36L2 protein levels, this antibody is an essential tool for studies aimed at understanding the molecular mechanisms underlying gene expression control. Its implications in diverse biological processes make it a valuable asset for researchers exploring the complexities of gene regulation and its implications for health and disease.
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane: NIH/3T3 cells, Primary antibody: PACO20704(ZFP36L2 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20704(ZFP36L2 Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors.
Synonyms:
ZFP36 ring finger protein-like 2
UniProt Protein Function:
ZFP36L2: Probable regulatory protein involved in regulating the response to growth factors. RNA-binding protein that binds to 5'UUAUUUAUUU-3' core sequence. Binds to the class II AU-rich element (ARE) in the 3'-UTR of target mRNAs and promotes their deadenylation and degradation.
UniProt Protein Details:
Protein type:Transcription factor
Chromosomal Location of Human Ortholog: 2p22.3-p21
Cellular Component: cytoplasm; nucleus
Molecular Function:AU-rich element binding; transcription factor activity
This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008]
