ZEB2 Transcription Factor Activity Assay

SKU:

TFAB00206

Product Type:

ELISA Kit

ELISA Type:

Transcription Factor Assay

Analytes:

ZEB2

Reactivity:

Human

Mouse

Rat

Description

Description

Datasheet

ZEB2 Transcription Factor Activity Assay

The ZEB2 Transcription Factor Activity Assay is a cutting-edge tool for studying the activity of the ZEB2 transcription factor in various biological samples. This assay kit provides high sensitivity and specificity, allowing for accurate and reproducible measurement of ZEB2 activity in cell lysates and tissue extracts.ZEB2 is a key regulator of epithelial-mesenchymal transition (EMT), a process involved in cancer progression and metastasis. By monitoring ZEB2 activity, researchers can gain valuable insights into the molecular mechanisms underlying EMT and identify potential therapeutic targets for cancer treatment.

With its user-friendly protocol and fast results, the ZEB2 Transcription Factor Activity Assay is an essential tool for researchers studying cancer biology, developmental biology, and other fields where ZEB2 signaling pathways play a critical role. Unlock the potential of your research with the ZEB2 Transcription Factor Activity Assay.

UniProt Protein Function:	ZEB2: Transcriptional inhibitor that binds to DNA sequence 5'- CACCT-3' in different promoters. Represses transcription of E- cadherin. Defects in ZEB2 are the cause of Mowat-Wilson syndrome (MWIS); also known as Hirschsprung disease-mental retardation syndrome. A complex developmental disorder characterized by mental retardation, delayed motor development, epilepsy, microcephaly and a wide spectrum of clinically heterogeneous features suggestive of neurocristopathies at the cephalic, cardiac, and vagal levels. Some patients manifest Hirschsprung disease. Affected patients show an easily recognizable facial appearance with deep set eyes and hypertelorism, medially divergent, broad eyebrows, prominent columella, pointed chin and uplifted, notched ear lobes. Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.
UniProt Protein Details:	Protein type:Motility/polarity/chemotaxis; Transcription, coactivator/corepressor; DNA-binding; C2H2-type zinc finger protein Chromosomal Location of Human Ortholog: 2q22.3 Cellular Component: nucleus Molecular Function:protein binding Biological Process: negative regulation of transcription from RNA polymerase II promoter; pigmentation during development; positive regulation of melanin biosynthetic process; positive regulation of melanocyte differentiation; positive regulation of transcription from RNA polymerase II promoter Disease: Mowat-wilson Syndrome
NCBI Summary:	The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]
UniProt Code:	O60315
NCBI GenInfo Identifier:	13124503
NCBI Gene ID:	9839
NCBI Accession:	O60315.1
UniProt Secondary Accession:	O60315,Q9UED1, A0JP09, B7Z2P2, F5H814,
UniProt Related Accession:	O60315
Molecular Weight:	133,806 Da
NCBI Full Name:	Zinc finger E-box-binding homeobox 2
NCBI Synonym Full Names:	zinc finger E-box binding homeobox 2
NCBI Official Symbol:	ZEB2
NCBI Official Synonym Symbols:	SIP1; SIP-1; ZFHX1B; HSPC082; SMADIP1
NCBI Protein Information:	zinc finger E-box-binding homeobox 2
UniProt Protein Name:	Zinc finger E-box-binding homeobox 2
UniProt Synonym Protein Names:	Smad-interacting protein 1; SMADIP1; Zinc finger homeobox protein 1b
Protein Family:	Zinc finger E-box-binding homeobox
UniProt Gene Name:	ZEB2
UniProt Entry Name:	ZEB2_HUMAN