The ZEB2 Polyclonal Antibody (CAB5705) is a valuable tool for researchers studying ZEB2, a transcription factor involved in regulating epithelial-to-mesenchymal transition (EMT) and cancer metastasis. This antibody, produced in rabbits, exhibits high reactivity with human samples and is specifically validated for use in Western blot applications.ZEB2 is a critical player in the process of EMT, which is implicated in promoting cancer metastasis by allowing tumor cells to become more invasive and migratory. By targeting ZEB2 with this antibody, researchers can better understand its role in driving cancer progression and potentially identify new therapeutic strategies for combating metastatic disease.
Furthermore, ZEB2 has been shown to influence various cellular processes beyond cancer, including stem cell pluripotency and neural development. The ability to detect and analyze ZEB2 expression in different cell types using this antibody makes it a versatile tool for investigating a range of biological phenomena beyond cancer biology.In summary, the ZEB2 Polyclonal Antibody (CAB5705) offers researchers a reliable means of studying ZEB2 function in a variety of contexts, ultimately advancing our understanding of its role in health and disease.
Product Name:
ZEB2 Rabbit Polyclonal Antibody
SKU:
CAB5705
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1050-1214 of human ZEB2 (NP_055610.1).
The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
9839
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ZEB2 Rabbit pAb (CAB5705) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
