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ZEB1 Polyclonal Antibody (CAB22244)

SKU:
CAB22244
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
$167 - $635
Frequently bought together:

Description

ZEB1 Polyclonal Antibody (CAB22244)

The ZEB1 Polyclonal Antibody (CAB22244) is a valuable tool for researchers studying ZEB1, a transcription factor involved in regulating epithelial-to-mesenchymal transition (EMT) and cell differentiation. This antibody, generated in rabbits, is highly specific for ZEB1 in human samples and has been validated for use in Western blot and immunohistochemistry applications.ZEB1 plays a critical role in various physiological and pathological processes, including embryonic development, wound healing, and cancer progression. Dysregulation of ZEB1 has been implicated in promoting tumor invasion and metastasis, making it a promising target for cancer research and therapeutic development.

The ZEB1 Polyclonal Antibody enables precise detection and analysis of ZEB1 expression in a variety of cell types, providing valuable insights into its function and potential as a therapeutic target.Researchers interested in understanding the molecular mechanisms underlying EMT, cancer progression, and other cellular processes influenced by ZEB1 will benefit from using the ZEB1 Polyclonal Antibody in their studies. Its high specificity and sensitivity make it an essential tool for investigating the role of ZEB1 in both normal physiology and disease states.

Product Name:ZEB1 Polyclonal Antibody
Product Code:CAB22244
Reactivity:Human, Rat
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Rat
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:HeLa, Jurkat, Rat heart
Cellular Location:cytosol, nucleoplasm, nucleus

This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 800-900 of human ZEB1 (NP_110378.3).
Sequence:INIAI PTVTA QLPTI VAIAD QNSVP CLRAL AANKQ TILIP QVAYT YSTTV SPAVQ EPPLK VIQPN GNQDE RQDTS SEGVS NVEDQ NDSDS TPPKK KMRKT E
Synonyms:BZP, TCF8, AREB6, FECD6, NIL2A, PPCD3, ZFHEP, ZFHX1A, DELTAEF1
Calculated MW:124kDa
Observed MW:200kDa

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