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ZEB1 Polyclonal Antibody (CAB21617)

SKU:
CAB21617
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
$155 - $431
Frequently bought together:

Description

ZEB1 Polyclonal Antibody (CAB21617)

The ZEB1 Polyclonal Antibody (CAB21617) is a valuable tool for researchers studying the role of ZEB1, a transcription factor involved in epithelial-to-mesenchymal transition (EMT) and metastasis in cancer. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the ZEB1 protein, researchers can investigate its expression and function in various cell types, making it an essential component of studies in oncology and cell biology.

ZEB1 is a critical regulator of EMT, a process that promotes cancer progression and metastasis by inducing changes in cell morphology and behavior. Its involvement in these processes makes it a potential therapeutic target for preventing cancer metastasis and improving patient outcomes. The ZEB1 Polyclonal Antibody enables researchers to explore the mechanisms underlying ZEB1-mediated EMT and metastasis, facilitating the development of novel cancer therapies and prognostic tools.

Product Name:ZEB1 Polyclonal Antibody
Product Code:CAB21617
Reactivity:Human
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Cellular Location:Nucleus

This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 490-710 of human ZEB1 (NP_110378.3).
Sequence:QNLKK ENPVA TNSCK SEKLP EDLTV KSEKD KSFEG GVNDS TCLLC DDCPG DINAL PELKH YDLKQ PTQPP PLPAA EAEKP ESSVS SATGD GNLSP SQPPL KNLLS LLKAY YALNA QPSAE ELSKI ADSVN LPLDV VKKWF EKMQA GQISV QSSEP SSPEP GKVNI PAKNN DQPQS ANANE PQDST VNLQS PLKMT NSPVL PVGST TNGSR SSTPS PSPLN L
Synonyms:BZP, TCF8, AREB6, FECD6, NIL2A, PPCD3, ZFHEP, ZFHX1A, DELTAEF1
Calculated MW:124kDa
Observed MW:Refer to figures

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